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Article

First-line treatment of EGFR-mutated non-small cell lung cancer with brain metastases: a systematic review and meta-analysis.

Scientific reports - 2 Oct 2024

Ma Jietao, Pang Xiaoxue, Zhang Shuling, Huang Letian, Sun Li, Han Chengbo

Abstract excerpt

This systematic review and network meta-analysis evaluates first-line treatment options for patients with EGFR-mutant non-small cell lung cancer (NSCLC) and brain metastases. We analyzed 24 randomized controlled trials (RCTs) involving 2,682 patients, comparing various EGFR tyrosine kinase inhibitors (TKIs) and combination therapies. Direct comparisons showed that the addition of bevacizumab or chemotherapy to...

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Antineoplastic Combined Chemotherapy Protocols
Bevacizumab
Brain Neoplasms
Carcinoma, Non-Small-Cell Lung
ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Progression-Free Survival

Protein Kinase Inhibitors

Randomized Controlled Trials as Topic

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Identifiers

PMID: 39358420
DOI: 10.1038/s41598-024-74496-0
PMCID: PMC11447023

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