Phenotypic and molecular detection of efflux pump and expression profiling genes in Klebsiella pneumoniae exposed to ciprofloxacin and amoxicillin/clavulanic acid.

Abstract excerpt

BACKGROUND: One of the main strategies Gram-negative bacteria employ to lower internal antibiotic concentrations is efflux. By identifying and eliminating a variety of harmful substances, including antibiotics, these active transport systems help bacteria become less susceptible to drugs and develop new resistance mechanisms. Efflux pumps are involved in bacterial stress response, pathogenicity, biofilm...

Topics

• Klebsiella pneumoniae
• Anti-Bacterial Agents
• Ciprofloxacin
• Membrane Transport Proteins
• Bacterial Proteins