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Article

A Direct-to-Biology Amine-Acid Amination for Rapid Phenotypic Profiling of Lysosomotropic Natural Products.

Journal of the American Chemical Society - 26 Aug 2026

Kao Yu-Ting, Abdelalim Mohamed, Mauro Carl, Douthwaite James L, McGrath Andrew, Meyer Sophia R, Singha Santanu, Flores Diaz Diana, Wang Mi, Wang Shaomeng, Sexton Jonathan Z, Cernak Tim

Abstract excerpt

Natural products (NPs) are foundational to drug discovery, owing to their diverse molecular scaffolds and novel bioactivities. However, optimizing NPs for optimal bioactivity and improved drug properties is hindered by material scarcity and labor-intensive purification processes. Here, we present an automated ultrahigh-throughput experimentation (ultraHTE) and direct-to-biology (D2B) platform that enables rapid...

Read the complete abstract on PubMed

Topics

Amination
Amines
Humans
Biological Products
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Cell Proliferation

Source

Open in PubMed Open full text

Identifiers

PMID: 42677575
DOI: 10.1021/jacs.6c06623
PMCID: PMC13680044

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