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Article

Causal relationships between oral-gut microbiome and bone neoplasm-related phenotypes: Insights from bidirectional Mendelian randomization.

Medicine - 28 Aug 2026

Zou Qinyu, Sun Fengyu, Xu Wantong, Peng Dan, Jiang Zhongbiao, Liao Hongchun

Abstract excerpt

The human oral and gut microbiota are the 4 largest microbial communities in the body and play crucial roles in maintaining homeostasis and influencing disease. Observational studies have suggested links between these microbiota and bone neoplasm-related phenotypes, but establishing causality has been challenging due to confounding factors and reverse causality. We conducted a bidirectional, 2-sample Mendelian...

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Topics

Humans
Mendelian Randomization Analysis
Phenotype
Gastrointestinal Microbiome
Saliva
Bone Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Mouth

Microbiota

Source

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Identifiers

PMID: 42675685
DOI: 10.1097/MD.0000000000050422
PMCID: PMC13529192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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