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Article

A Two-Sample Mendelian Randomisation Analysis of the Oral Microbiome and Oral/Oropharyngeal/Tongue Cancers.

Oral health & preventive dentistry - 12 Aug 2026

Han Leng, Wu Xinxuan, Gong Beini, Li Xun, Li Xiao, Wang Zhifa

Abstract excerpt

OBJECTIVE: To assess the potential causal relationships of the oral microbiome with the risks of oral cancer, oropharyngeal cancer, and tongue cancer using two-sample Mendelian randomisation (MR) analysis, while distinguishing these from reverse causal effects of the cancers on microbial abundance. METHODS AND MATERIALS: Using single-nucleotide polymorphisms as instrumental variables, we applied the MR...

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Identifiers

PMID: 42583788
DOI: 10.3290/j.ohpd.c_2778
PMCID: PMC13469316

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