Association between preoperative MRI radiomic features and methylation-defined phenotypes in non-functioning pituitary adenomas.

doi:10.1007/s11102-026-01755-w

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Article

Association between preoperative MRI radiomic features and methylation-defined phenotypes in non-functioning pituitary adenomas.

Pituitary - 31 Aug 2026

Djebbara Ilies, Møller Morten Winkler, Christensen Ivar Yannick, Halle Bo, Pedersen Christian Bonde, Poulsen Frantz Rom, Aunan-Diop Jan Saip

Abstract excerpt

PURPOSE: DNA methylation profiling identifies clinically relevant subgroups of non-functioning pituitary adenomas (NFPAs), but requires tumour tissue and is unavailable preoperatively. We investigated whether reported outcome-associated methylation-defined NFPA phenotypes are associated with preoperative MRI radiomic features. METHODS: We performed a single-centre retrospective radiogenomic analysis nested within...

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Topics

Humans
Magnetic Resonance Imaging
Radiomics
Female
Male
Pituitary Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Methylation

Middle Aged

Retrospective Studies

Phenotype

Adenoma

Aged

Adult

Source

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Identifiers

PMID: 42671655
DOI: 10.1007/s11102-026-01755-w
PMCID: PMC13529862

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