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Article

[HAVCR2-mutated subcutaneous panniculitis-like T-cell lymphoma presenting with bone marrow infiltration and rapidly fatal hemophagocytic lymphohistiocytosis].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2026

Osada Makoto, Yamazaki Kohei, Kunieda Hisako, Tsukada Yuiko, Kim Haryoon, Mizuno Kota, Ito Yuta, Kogure Yasunori, Kataoka Keisuke, Hirose Shigemichi, Kikuchi Takahide

Abstract excerpt

A 37-year-old man presented with recurrent fever. Diagnosis was challenging due to the lack of localized physical findings; however, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) was eventually confirmed through multiple bone marrow biopsies. The patient developed rapidly progressive liver failure and hemophagocytic lymphohistiocytosis (HLH), resulting in a severe bleeding tendency. Despite receiving...

Read the complete abstract on PubMed

Topics

Humans
Lymphohistiocytosis, Hemophagocytic
Male
Adult
Panniculitis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Lymphoma, T-Cell

Bone Marrow

Fatal Outcome

Mutation

Germ-Line Mutation

Source

Identifiers

PMID: 42669505
DOI: 10.11406/rinketsu.67.916

Genes

HAVCR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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[HAVCR2-mutated subcutaneous panniculitis-like T-cell lymphoma presenting with bone marrow infiltration and rapidly fatal hemophagocytic lymphohistiocytosis].PMID 42669505Read ↗

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