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Article

Ruxolitinib Monotherapy for a Child With HAVCR2 Gene Mutation Associated Subcutaneous Panniculitis-like T-cell Lymphoma: A Case Report.

Journal of pediatric hematology/oncology - 1 Jul 2024

Zhang Gege, Zhou Chunju, Wei Ang, Zhang Rui, Zhao Yunze, Ma Honghao, Lian Hongyun, Wang Dong, Wang Tianyou

Abstract excerpt

BACKGROUND: The occurrence of hemophagocytic lymphohistiocytosis (HLH) in patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL) may be due to HAVCR2 gene mutation, leading to T-cell immunoglobulin and mucin domain-containing molecule 3 deficiency, T-cell and macrophage activation, and proinflammatory cytokine production. OBSERVATION: We report a patient with SPTCL and HLH for whom ruxolitinib, used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38748615
DOI: 10.1097/MPH.0000000000002868

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