Article
Wastewater-Based Genomic Surveillance of SARS-CoV-2 Antiviral Resistance Determinants in Ontario: Towards a Scalable Framework for Population-Level Antiviral Resistance Monitoring.
Viruses - 21 Aug 2026
Lawal Opeyemi U, Parreira Valeria R, Overton Alyssa K, Knapp Jennifer J, Gibson Richard, Arts Eric J, Zhang Linkang, Rizvi Fozia, Precious Melinda, Charles Trevor C, Goodridge Lawrence
Abstract excerpt
BACKGROUND: Wastewater surveillance has emerged as an effective tool for population-level pathogen monitoring. Its application to mutations associated with resistance to antivirals remains comparatively underdeveloped. We assessed the wastewater epidemiology framework using SARS-CoV-2 as a model pathogen to evaluate spatial, temporal, and therapeutic class-specific resistance dynamics. METHODS: We analyzed about...
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