Article
Chemical Annotation and Biological Evaluation of Prenylated Benzophenone-Rich Fractions from Clusia grandiflora Fruits: Integrated In Vitro and In Silico Analyses of Antileishmanial Activity, Nitric Oxide Modulation, and Stage-Dependent Cell Death Phenotypes.
Molecules (Basel, Switzerland) - 16 Aug 2026
de Jesus Alves Miranda Amanda, de Jesus Caroline Martins, Valenzuela Kassandra Gómez, Burgos José Alberto Pérez, Dos Santos Soares Buna Samuel, Carvalho Lívia Maria Martins, Marinho Lucas Cardoso, de Sousa Lima Neto José, Silva Marcelo José Dias, Lopes Alberto Jorge Oliveira, Silva Lucilene Amorim, Rascón Valenzuela Luisa Alondra, da Rocha Cláudia Quintino
Abstract excerpt
Clusia grandiflora Splitg. (Clusiaceae), popularly known as "cebolão" or "orelha-de-onça", is a Neotropical species recognized as a rich source of bioactive secondary metabolites, particularly prenylated benzophenones. This study investigated the chemical composition and antileishmanial potential of the ethanolic extract (EBCG), dichloromethane fraction (FDCG), and hexane fraction (FHex) obtained from C....
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