Article
The Non-Coding rs5945619 Variant at Xp11.22 and Its Putative Regulatory Effects on Nearby Genes in Ecuadorian Mestizo Women with Breast Cancer: A Case Series and In Silico Cis-eQTL Analysis.
International journal of molecular sciences - 7 Aug 2026
Tamayo-Trujillo Rafael, Zambrano Ana Karina, Guevara-Ramírez Patricia, Paz-Cruz Elius, Ruiz-Pozo Viviana A, Cadena-Ullauri Santiago, Llerena Béjar Luis Israel
Abstract excerpt
Breast cancer (BC) is a heterogeneous disease influenced by genetic and regulatory mechanisms. Despite this, X-linked non-coding variants remain underexplored, particularly in admixed Latin American populations. Therefore, this study aimed to characterize the non-coding variant rs5945619 at Xp11.22 in Ecuadorian mestizo women with BC and to assess its potential regulatory effects on nearby genes through in silico...
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