Systems Bioengineering of Septic Shock Metabolism: Citrulline, β-Hydroxybutyrate and Plasma Biomarker-Based Phenotyping.

doi:10.3390/biom16081189

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Article

Systems Bioengineering of Septic Shock Metabolism: Citrulline, β-Hydroxybutyrate and Plasma Biomarker-Based Phenotyping.

Biomolecules - 14 Aug 2026

Azamfirei Leonard, Cehan Vlad Dimitrie, Cehan Alina Roxana, Pui Mihai Claudiu, Lazar Alexandra

Abstract excerpt

BACKGROUND: Although advances in critical care have improved short-term outcomes, sepsis survivors continue to face substantial chronic morbidity and impaired long-term survival. Conventional threshold-based tools such as the Sequential Organ Failure Assessment (SOFA) and Modified Early Warning Score (MEWS) show moderate and variable discrimination across cohorts. Reported areas under the receiver operating...

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PMID: 42650855
DOI: 10.3390/biom16081189
PMCID: PMC13511653

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