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Article

Multi-Omic Analysis of Cerebrospinal Fluid Metabolites in Autism Spectrum Disorder: Biomarker Identification, Metabolic Genetics Insights, and Network Toxicology.

Genes - 27 Jul 2026

Zhao Dan, Guo Junzhi, Zhang Ying, Lan Yuanfeng, Zhao Tian, Xu Yiliang, Yang Qizhou, Ye Haihong

Abstract excerpt

Background: Although genetic-environmental interactions are established in autism spectrum disorder (ASD), how environmental toxicants confer susceptibility remains unclear. This study aimed to investigate potential relationship between genetically predicted cerebrospinal fluid (CSF), metabolite levels and ASD liability, and to prioritize regulatory genes, key pathways, and candidate environmental toxicants....

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Source

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Identifiers

PMID: 42650067
DOI: 10.3390/genes17080874
PMCID: PMC13512186

Genes

GRM8
KATNA1
KATNAL2

Provenance

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