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Article

Generation of two induced pluripotent stem cell lines from Marfan syndrome patients carrying FBN1 mutations.

Stem cell research - 1 Sept 2026

Mui Byron W H, Chorsi Mey-Sam, Yan Christopher D, Chao Jade T, Wu Joseph C

Abstract excerpt

Marfan syndrome is a connective tissue disorder affecting the cardiovascular, skeletal, and ocular systems. Here, we generated and characterized induced pluripotent stem cell (iPSC) lines derived from two Marfan syndrome patients with mutations in the FBN1 gene (c.3333C > A and c.8854_8562delinsTATCAC). Both lines exhibited typical iPSC morphology, normal karyotype, undifferentiated states, and trilineage...

Read the complete abstract on PubMed

Topics

Humans
Marfan Syndrome
Induced Pluripotent Stem Cells
Fibrillin-1
Adipokines
Mutation
Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line

Female

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 42648118
DOI: 10.1016/j.scr.2026.104087
PMCID: PMC13634669

Genes

FBN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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