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PHENOTYPIC SHIFT OF ADENOCARCINOMA TO SQUAMOUS CELL CARCINOMA OF RECTUM AFTER NEOADJUVANT CHEMORADIOTHERAPY WITH DETECTION OF HPV16: A CLINICAL CASE.

Experimental oncology - 21 Aug 2026

Kovalyov O, Zavhorodniy S, Tolok O, Anenko A, Kubrak M, Danilyuk M, Kovalyov K

Abstract excerpt

Adenosquamous carcinoma and pure squamous cell carcinoma (SCC) of the rectum are extremely rare malignancies, accounting for approximately 0.15% of all colorectal cancers. Increasing attention has been paid to tumor phenotypic plasticity in the context of intensive anticancer therapy. We report the case of a 45-year-old patient with locally advanced rectal adenocarcinoma (cT4bN2M0) who underwent total neoadjuvant...

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Adenocarcinoma
Biomarkers, Tumor
Carcinoma, Squamous Cell
Chemoradiotherapy
Human papillomavirus 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoadjuvant Therapy

Papillomavirus Infections

Rectal Neoplasms

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Identifiers

PMID: 42634839
DOI: 10.15407/exp-oncology.2026.02.172

Genes

CDX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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