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Article

Dysfunction of Primary Cilium in Huntington's Disease: How Mutant Huntingtin Disrupts This Cellular Signaling Hub.

Biochemistry. Biokhimiia - 1 Jul 2026

Churkina Aleksandra S, Shakhov Anton S, Alieva Irina B

Abstract excerpt

Primary cilia are solitary, antenna-like organelles that project from the surface of most vertebrate cells. They consist of a microtubule-based axoneme extending from a modified centriole (basal body) and enclosed by a lipid bilayer membrane. For several decades after their discovery, the functions of primary cilia had remained speculative; they were even considered vestigial structures. Currently, primary cilium...

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Identifiers

PMID: 42633714
DOI: 10.1134/S0006297926601590

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PCM1

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