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Comprehensive Genomic Analysis of the pO157 Plasmid in Enterohemorrhagic Escherichia coli O157:H7 Reveals Non-synonymous Variation in Virulence Factors.

Current microbiology - 20 Aug 2026

Smith Libia Yael, Farace Pablo Daniel, Sabio Y García Julia, Vilte Daniel, Riviere Nahuel, Larzábal Mariano, Cataldi Angel, Marques Da Silva Wanderson

Abstract excerpt

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen responsible for severe human diseases, including hemolytic uremic syndrome. Its virulence plasmid, pO157, encodes toxins, proteases, and adhesins; however, the extent of genetic variability among strains remains poorly characterized. Here, we analyzed 153 complete pO157 sequences using comparative pan-genomic and structural approaches....

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PMID: 42622701
DOI: 10.1007/s00284-026-05126-3

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GC

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