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A Rare Combination of von Willebrand Disease Type 2A and 2M: Diagnostic and Therapeutic Challenges - A case report.

Research and practice in thrombosis and haemostasis - 1 Jul 2026

Derikx Floor, Merry Inge, Willemsen Dennis, Beckers Erik, Henskens Yvonne, Heubel-Moenen Floor

Abstract excerpt

Background: Combined von Willebrand disease (VWD) type 2A/2M is a rare phenotype characterized by overlapping qualitative defects affecting both multimer structure and von Willebrand factor (VWF) function. Key Clinical Question: How can congenital VWD be distinguished from acquired von Willebrand syndrome (AVWS) when both conditions contribute to an abnormal laboratory phenotype? Clinical Approach: A 73-year-old...

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Identifiers

PMID: 42620776
DOI: 10.1016/j.rpth.2026.106867
PMCID: PMC13485626

Genes

VWF

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