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Article

Targeted sequencing provides genetic insights into familial cardiovascular disease among young adults in a high consanguinity population.

PloS one - 1 Jan 2026

Arif Nauman, Khan Imran, Khan Taj Ali, Ahmad Sajjad, Nauman Fatima, Ahmad Gulzar, Ijaz Muhammad, Ahmad Bilal, Hassan Syed Munawar, Afaq Saima, Haq Zia Ul

Abstract excerpt

BACKGROUND: Cardiovascular diseases (CVDs) account for approximately 19.8 million deaths annually, with coronary artery disease (CAD) as a major contributor. Genetic factors play an important role in CVD development. Genetic risk can be attributed to monogenic and polygenic risk variants. Patients with rare, Mendelian monogenic CVDs have been shown to have mutations in many causative genes, including LRP6, MEF2A,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42594142
DOI: 10.1371/journal.pone.0353861
PMCID: PMC13472394

Genes

CYP27A1
LRP6
CAD
ST6GALNAC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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