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Article

Systematic Benchmarking of DNA Sequence Encoding Strategies for Predicting Regulatory Effects of Non-Coding SNPs.

International journal of molecular sciences - 25 Jul 2026

Jin Hui, Bao Yihang, Li Wenhao, Yang Chengyi, Wang Weidi, Cai Wenxiang, Liu Zhe, Lin Guan Ning

Abstract excerpt

Non-coding single nucleotide polymorphisms (SNPs) are key modulators of gene regulation and have been implicated in diverse complex traits and diseases. With the growing demand for accurate functional interpretation of non-coding variants, the choice of encoding strategies becomes critical in downstream predictive modeling. Despite recent advances, a systematic evaluation of encoding approaches tailored for...

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PMID: 42589315
DOI: 10.3390/ijms27156657
PMCID: PMC13465526

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