Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

Abstract excerpt

Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the oral microbiota is regarded as highly dynamic. Here, we report significant human genomic associations with the oral metagenome from more than 1915 individuals, for both the tongue dorsum ( n = 2017) and saliva ( n =...