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Characterization of putative germline pathogenic variants in 27 candidate cancer-predisposing genes in 813 cats using a feline-specific multiplex targeted sequencing.

Scientific reports - 8 Aug 2026

Ikeda Namiko, Mizukami Keijiro, Yamada Ryoko, Toyoda Hiroto, Aoi Tomomi, Endo Mikiko, Iwasaki Yusuke, Kato Daiki, Nakagawa Takayuki, Nishimura Ryohei, Tomiyasu Hirotaka, Momozawa Yukihide

Abstract excerpt

In humans, about 5-10% of all cancers are caused by germline pathogenic variants (PVs) in cancer-predisposing genes, and their identification enables precision oncology approaches, such as surveillance for early detection, preventive medicine, and targeted therapy. Although cancer is a leading cause of death in cats, PVs have not been investigated for precision oncology. We developed a feline-specific multiplex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42570956
DOI: 10.1038/s41598-026-61718-w
PMCID: PMC13452813

Genes

ATM
BRCA2
MSH2
MSH6
RAD51C

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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