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Article

Generation of an induced pluripotent stem cell line (HMSCATi007-A) from an epileptic patient with DEPDC5 gene mutation.

Stem cell research - 1 Sept 2026

Li Xinwei, Chunyan Zuo, Lu Mengcao, Wang Jiaxuan, Ren Wenjing, Shan Wei, Ren Qian, Wang Qun

Abstract excerpt

Familial Focal Epilepsy with Variable Foci 1 (FFEVF1) is an autosomal dominant epilepsy disorder characterized by focal seizures. Induced pluripotent stem cells (iPSCs) were derived from a 21-year-old epileptic patient carrying a heterozygous DEPDC5 c.2748 (C > G) (exon 29) variant. The derived iPSCs maintain a normal karyotype, express pluripotency markers, and retain the ability to differentiate into the three...

Read the complete abstract on PubMed

Topics

Humans
Induced Pluripotent Stem Cells
Mutation
Young Adult
Epilepsy
Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

GTPase-Activating Proteins

Cell Line

Male

Source

Identifiers

PMID: 42561553
DOI: 10.1016/j.scr.2026.104067

Genes

DEPDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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