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Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen.

Renal failure - 1 Dec 2026

Zeng Dianjie, Zhu Lingfei, Shi Li, Wang Yuxi, Liu Jiachen, Peng Yi, Zhao Xiaokun, Wang Yinhuai, Sun Liya, He Haiqing

Abstract excerpt

The long-term renal implications of conditions leading to male reproductive surgeries remain unclear. This study evaluated the potential causal relationships between genetic liability to undergoing these surgeries and kidney diseases. Genetic variants associated with four surgery-related phenotypes-testicular hydrocele surgery, testicular or scrotal surgery, circumcision, and vasectomy-were selected as...

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Genetic Predisposition to Disease
Kidney Diseases
Mendelian Randomization Analysis
UK Biobank
United Kingdom

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42549566
DOI: 10.1080/0886022X.2026.2696181
PMCID: PMC13439781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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