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Article

Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2026

Witz Andréa, Conroy Thierry, Lambert Aurélien, Salleron Julia, Diallo Aboubacar, Husson Marie, Nicolle Rémy, Hammel Pascal, Biagi James, Renouf Daniel J, Turpin Anthony, Richard Corentin, Bachet Jean-Baptiste, Iovanna Juan, Dusetti Nelson, Monard Laure, Mauduit Marjorie, Cros Jérôme, Harlé Alexandre

Abstract excerpt

PURPOSE: Modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX/mFFX) is the standard adjuvant chemotherapy for resected pancreatic ductal adenocarcinoma (PDAC), offering survival benefits over gemcitabine (GEM). However, the contribution of molecular biomarkers to treatment selection remains unclear. Here, we characterize the molecular landscape of tumors from the PRODIGE-24/CCTG PA6 trial...

Read the complete abstract on PubMed

Topics

Humans
Pancreatic Neoplasms
Chemotherapy, Adjuvant
Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Fluorouracil

Oxaliplatin

Carcinoma, Pancreatic Ductal

Leucovorin

Male

Mutation

Irinotecan

Deoxycytidine

Aged

Middle Aged

Gemcitabine

Disease-Free Survival

Adenocarcinoma

Source

Open in PubMed Open full text

Identifiers

PMID: 42546248
DOI: 10.1200/JCO-25-02508
PMCID: PMC13557492

Genes

GEM
KRAS

Provenance

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