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Article

A Functional SNP in the Promoter Region of Ovine IDO2 Associated With Melatonin Levels via Affecting Transcription Activity by CLOCK.

Animal genetics - 1 Aug 2026

Jiang Xunping, Chi Shaxuan, Wang Xiaodong, Chen Mengya, Tie Zhuoying, Yang Huiguo, Wang Chaoli, Liu Guiqiong

Abstract excerpt

Sheep seasonal reproduction is regulated by photoperiod via melatonin. Indoleamine 2,3-dioxygenase 2 (IDO2), an enzyme involved in tryptophan metabolism through the kynurenine pathway and belonging to the IDO family, may contribute to melatonin homeostasis, but its role in reproductive seasonality remains unclear. In this study, genome-wide selection analyses combining Z(FST) and XP-EHH between seasonal and...

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Share to CLOCK Proteins
Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melatonin

Share to Photoperiod

Share to Promoter Regions, Genetic

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Share to Sheep, Domestic

Share to Transcription, Genetic

Source

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Identifiers

PMID: 42543215
DOI: 10.1002/age.70173
PMCID: PMC13429496

Genes

IDO2
CLOCK
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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