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Article

Conversion surgery after BRAF-directed therapy for unresectable papillary thyroid carcinoma with severe tracheal invasion.

Auris, nasus, larynx - 1 Oct 2026

Ichikawa Ryoga, Yamada Masato, Ae Keitaro, Yanagi Hidenari, Nigauri Haruhiko

Abstract excerpt

Locally advanced papillary thyroid carcinoma (PTC) with invasion of the airway and major vessels presents a significant therapeutic challenge. Although multikinase inhibitors (mTKIs) are effective for unresectable thyroid carcinoma, their antiangiogenic effects may increase the risk of life-threatening hemorrhage in patients with major vessel invasion or intraluminal airway exposure. Recent advances in...

Read the complete abstract on PubMed

Topics

Humans
Male
Thyroid Neoplasms
Proto-Oncogene Proteins B-raf
Imidazoles
Aged
Pyridones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Thyroid Cancer, Papillary

Thyroidectomy

Neoplasm Invasiveness

Pyrimidinones

Oximes

Neck Dissection

Tracheal Neoplasms

Trachea

Antineoplastic Combined Chemotherapy Protocols

Tomography, X-Ray Computed

Mutation

Source

Identifiers

PMID: 42532726
DOI: 10.1016/j.anl.2026.07.004

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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