Identification of Clinical Sub-Phenotypes of Sickle Cell Disease Using Latent Class Analysis.

Abstract excerpt

Sickle cell disease (SCD), a monogenic disorder, exhibits variable severity due to genetic and environmental modifiers. Prior studies have proposed hemolytic and vaso-occlusive sub-phenotypes based on limited data. We used latent class analysis (LCA) to identify complication-based sub-phenotypes in a large longitudinal cohort. From California administrative databases (1991-2019), we assembled a cohort of 7636 SCD...

Topics

• Humans
• Anemia, Sickle Cell
• Female
• Male
• Latent Class Analysis
• Adult
• Phenotype