Exploring the association between genetic variation in selenoprotein genes (GPX1 and SELENOP) and biomarkers of selenium status in bipolar disorder: Evidence from a case-control study from the North African population.

doi:10.1016/j.jtemb.2026.127933

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Article

Exploring the association between genetic variation in selenoprotein genes (GPX1 and SELENOP) and biomarkers of selenium status in bipolar disorder: Evidence from a case-control study from the North African population.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) - 1 Oct 2026

Chebieb Ikram, Medjati Nouria Dennouni, Dali-Sahi Majda, Harek Yahia, Kaprio Jaakko

Abstract excerpt

Selenium (Se) is an essential micronutrient that exerts an antioxidant role in the brain through selenoproteins; its dysregulation may be implicated in bipolar disorder (BD). This study investigates the association between Se status and BD risk, focusing on the impact of SNPs in glutathione peroxidases1 (GPX1) and selenoprotein P (SELENOP) on selenium metabolism and BD risk. A total of 32 patients with BD and 38...

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Topics

Adult
Female
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Biomarkers

Bipolar Disorder

Case-Control Studies

Genetic Variation

Glutathione Peroxidase

Glutathione Peroxidase GPX1

Polymorphism, Single Nucleotide

Selenium

Selenoprotein P

Selenoproteins

Africa, Northern

Source

Open in PubMed

Identifiers

PMID: 42526346
DOI: 10.1016/j.jtemb.2026.127933

Genes

GPX1
SELENOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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