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Article

Transcriptomic Stratification Reveals an FRS2-Associated, Proliferation-Independent Phenotype in MDM2-High Sarcomas.

Current oncology (Toronto, Ont.) - 22 Jul 2026

Sakai Takao, Aiba Hisaki, Yamaguchi Makoto, Hagiwara Koji, Murakami Hideki, Kimura Hiroaki

Abstract excerpt

Sarcomas with Murine Double Minute 2 (MDM2) amplification are considered potential candidates for MDM2-targeted therapy. However, the limited efficacy of MDM2 inhibitor monotherapy suggests that additional biological factors may influence tumor behavior and prognosis. This study investigated the relationship between MDM2 expression and the Complexity Index in SARComas (CINSARC) transcriptomic signature, a gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42505239
DOI: 10.3390/curroncol33070438
PMCID: PMC13407697

Genes

MDM2
FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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