Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causal association between hip osteoarthritis and the risk of pancreatic cancer: A bidirectional two-sample Mendelian randomization study.

Medicine - 24 Jul 2026

Li Wei, Hu Bo, Zhuang Hongyu

Abstract excerpt

The potential causal relationship between hip osteoarthritis (HOA) and pancreatic cancer (PC) is not well understood. To investigate this, our study utilized a two-sample Mendelian randomization (MR) method to examine a possible causal link between HOA and an increased risk of PC. Genome-wide association study summary data for both HOA and PC were sourced from the Integrative Epidemiology Unit OpenGWAS database...

Topics

Join the communities discussing this publication.

PC gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Osteoarthritis, Hip

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42499097
DOI: 10.1097/MD.0000000000049859
PMCID: PMC13406371

Genes

PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causal association between hip osteoarthritis and the risk of pancreatic cancer: A bidirectional two-sample Mendelian randomization study.PMID 42499097Read ↗

Causal relationship between periodontal disease-related phenotype and knee osteoarthritis: A two-sample mendelian randomization analysis.Semantic proximity Read ↗

The causal relationship between osteoarthritis and bladder cancer: A Mendelian randomization study.Semantic proximity Read ↗

Potential causal relationship between body mass index (BMI) and acute pancreatitis: a Mendelian randomization studySemantic proximity Read ↗

Causal Associations of Circulating Lipids with Osteoarthritis: A Bidirectional Mendelian Randomization Study.Semantic proximity Read ↗

Causal relationships between obesity and pancreatobiliary diseases: a two-sample Mendelian randomization study.Semantic proximity Read ↗

Causal relationship between osteoporosis and osteoarthritis: A two-sample Mendelian randomized study.Semantic proximity Read ↗

Association of demographic and clinical factors with risk of acute pancreatitis: An exposure-wide Mendelian randomization study.Semantic proximity Read ↗

The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

A MR-PheWAS and bidirectional Mendelian randomization study: Exploring for causal relationships of pancreatic cancer.Semantic proximity Read ↗

35 blood and urine biomarkers and digestive system cancers: A two-sample Mendelian randomization study.Semantic proximity Read ↗

Causal Relationships Between Osteoarthritis and Senile Central Nerve System Dysfunction: A Bidirectional Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

Genetically predicted obesity and risk of hip osteoarthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.