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Article

UBTD1 Drives Ovarian Cancer Progression via Mutation-Associated Alterations, Stromal Microenvironment Remodeling, and TNF/AP-1 Signaling.

Human mutation - 1 Jan 2026

Liu Aixin, Chen Yanxia, Zhao Xian, Zhou Junying, Feng Guanying, Zhang Huijuan, Liu Baiyang, Chen Yongbin, Yang Cuiping

Abstract excerpt

Background: The ubiquitin domain-containing protein 1 (UBTD1) is involved in protein homeostasis and cell cycle regulation, and emerging evidence suggests its role in tumor biology. However, its function in ovarian cancer (OC) remains unclear. OC is highly lethal due to late diagnosis, metastasis, and platinum resistance. This study is aimed at investigating the role of UBTD1 in OC by integrating single-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42488496
DOI: 10.1155/humu/9479429
PMCID: PMC13390016

Genes

UBTD1
FOS
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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