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Article

Genetic and biological mechanisms of pediatric enuresis: integrating pathophysiology, GWAS associations, and multi-omics research.

European journal of pediatrics - 22 Jul 2026

Wu Pei, Chen Jia, Chen Zhu

Abstract excerpt

Pediatric enuresis is a common developmental disorder involving involuntary nocturnal voiding. This review synthesizes current evidence on its neurodevelopmental, renal, circadian, and genetic underpinnings. Traditional classification into monosymptomatic and non-monosymptomatic forms guides treatment but does not fully capture underlying biological heterogeneity. Genome-wide association studies have identified...

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PMID: 42484710
DOI: 10.1007/s00431-026-07191-z

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AVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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