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Article

Genetic Contributions to Lower Urinary Tract Dysfunction.

American journal of medical genetics. Part A - 1 Jan 2025

Hiltebeitel Lilian R, Seltzsam Steve, Wang Chunyan, Lee Ted, Bolsius Leah, Shalaby Mohamed, El Desoky Sherif, Kari Jameela A, Shril Shirlee, Hildebrandt Friedhelm, Mann Nina

Abstract excerpt

Lower urinary tract dysfunction (LUTD) can manifest as a spectrum of voiding symptoms in childhood, including urinary urgency, frequency, hesitancy, and incontinence. In severe cases, it can lead to frequent urinary tract infections, hydronephrosis, kidney scarring, and chronic kidney disease. Non-neurogenic neurogenic bladder (NNNB) is a diagnosis of exclusion in which children develop discoordination between...

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Identifiers

PMID: 39229650
DOI: 10.1002/ajmg.a.63859
PMCID: PMC11637931

Genes

HPSE2
ARL6

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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