Article
CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights.
PloS one - 1 Jan 2026
Zeng Qiang, Tao Junfeng, Peng Guangbei, Qin Lilu, Wu Shuzhen, Wang Chen, Liu Zhong, Zeng Linshan
Abstract excerpt
BACKGROUND: Wilms tumor (WT) is a prevalent pediatric renal malignancy, yet its molecular mechanisms remain poorly defined. Identifying key prognostic genes and understanding their functional roles is critical for improving clinical management. This study aimed to identify prognostic genes in WT and to investigate whether ATP5F1A functions as a candidate downstream effector in a CDCA8-associated regulatory axis....
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