Outcomes and Molecular Correlates of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases.

doi:10.1097/DCR.0000000000004379

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Outcomes and Molecular Correlates of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Metastases.

Diseases of the colon and rectum - 1 Oct 2026

Liesegang Amanda G, Powell Halle Kisandra, Jain Anshini, Flood Michael P, Mohan Helen M, Warrier Satish K, Clemons Nicholas J, Ramsay Robert G, Tie Jeanne, Michael Michael, Heriot Alexander G, Guerra Glen

Abstract excerpt

BACKGROUND: Colorectal peritoneal metastases occur in ~13% of colorectal cancer cases. The median survival with systemic chemotherapy alone is 10 to 18 months. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy can extend survival to ~41 months, but judicious patient selection is crucial. OBJECTIVE: This study aimed to describe outcomes of cytoreductive surgery and hyperthermic intraperitoneal...

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Topics

Humans
Peritoneal Neoplasms
Hyperthermic Intraperitoneal Chemotherapy
Female
Cytoreduction Surgical Procedures

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Colorectal Neoplasms

Retrospective Studies

Male

Proto-Oncogene Proteins B-raf

Middle Aged

Proto-Oncogene Proteins p21(ras)

Aged

Disease-Free Survival

Mutation

Treatment Outcome

Adult

Combined Modality Therapy

Source

Open in PubMed

Identifiers

PMID: 42478487
DOI: 10.1097/DCR.0000000000004379

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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