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Article

Association between autoimmune thyroiditis and BRAFV600E/TERT promoter mutations in patients with papillary thyroid carcinoma from Central Asia, Kazakhstan.

PloS one - 1 Jan 2026

Kaidarova Saya, Mussazhanova Zhanna, Kozykenova Zhanna, Kurohama Hirokazu, Targynova Akbota, Dyussupov Altay, Yeleubayeva Zhanar, Nakashima Masahiro

Abstract excerpt

BACKGROUND: Autoimmune thyroiditis (AIT), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), frequently coexists with papillary thyroid carcinoma (PTC). Chronic inflammation may influence thyroid carcinogenesis; however, the relationship between AIT and aggressive molecular alterations in PTC, particularly BRAFV600E and TERT promoter mutations, remains unclear. Data from iodine-deficient regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

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Share to Thyroid Cancer, Papillary

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Source

Open in PubMed Open full text

Identifiers

PMID: 42475304
DOI: 10.1371/journal.pone.0351960
PMCID: PMC13384275

Genes

TERT
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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