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Article

Interplay of BRAF and TERT promoter mutations and Ki67 proliferation index in papillary thyroid carcinoma in Central Asians.

BMC endocrine disorders - 21 May 2026

Targynova Akbota, Mussazhanova Zhanna, Bychkov Andrey, Kurohama Hirokazu, Tlegenov Askar, Adilbay Dauren, Yeleubayeva Zhanar, Dushimova Zaure, Akhayeva Tamila, Kondo Hisayoshi, Nakashima Masahiro

Abstract excerpt

BACKGROUND: Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid carcinoma, constituting 80-85% of all cases. The clinical challenges posed by PTC are further compounded by its steadily increasing global incidence. Primarily associated with mutations in BRAF V600E and the TERT promoter (TERTp), the aggressive clinicopathological features and poor prognosis of PTC are exacerbated when these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42169021
DOI: 10.1186/s12902-026-02306-x
PMCID: PMC13371233

Genes

BRAF
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Interplay of BRAF and TERT promoter mutations and Ki67 proliferation index in papillary thyroid carcinoma in Central Asians.PMID 42169021Read ↗

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