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Mitochondrial DNA genetic variants are associated with systemic lupus erythematosus susceptibility, glucocorticoids efficacy and prognosis.

Rheumatology (Oxford, England) - 30 May 2022

Teng Ying, Yan Zi-Ye, Wang Lin-Lin, Wang Yu-Hua, Zhang Ting-Yu, Li Zhen, Liu Shuang, Cai Jing, Chen Yang-Fan, Li Mu, Liu Sheng-Xiu, Xu Zhou-Zhou, Huang Hai-Liang, Wang Fang, Pan Fa-Ming, Pan Hai-Feng, Su Hong, Zou Yan-Feng

Abstract excerpt

OBJECTIVE: To investigate the associations of mitochondrial DNA (mtDNA) genetic variants with SLE susceptibility, glucocorticoid (GC) efficacy and prognosis. METHODS: Our study was done in two stages. First, we performed whole mitochondrial genome sequencing in 100 patients and 100 controls to initially screen potential mtDNA variants associated with disease and GC efficacy. Then, we validated the results in an...

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Share to DNA, Mitochondrial
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucocorticoids

Share to Lupus Erythematosus, Systemic

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 34718439
DOI: 10.1093/rheumatology/keab806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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