Article
Impact of cyst maturity on drug resistance assays in Acanthamoeba Genotype T4.
International journal for parasitology. Drugs and drug resistance - 1 Aug 2026
Chen Chun-Hsien, Wu Ya-Na, Tsai Chih Ming, Wu Shang-Rung, Lin Wei-Chen
Abstract excerpt
Therapeutic failure in Acanthamoeba Keratitis (AK) is largely driven by the high resistance of cysts to antimicrobial agents. However, the development of effective cysticidal drugs is hindered by the lack of standardized in vitro encystation protocols. Inconsistencies in induction methods can produce immature cells that lack the structural defenses of mature clinical walls, potentially leading to false-positive...
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