Article
Identifying differentially expressed genes in trophozoites and cysts of Acanthamoeba T4 genotype: Implications for developing new treatments for Acanthamoeba keratitis.
European journal of protistology - 1 Feb 2015
Abedkhojasteh Hoda, Niyyati Maryam, Rezaei Sasan, Mohebali Mehdi, Farnia Shohreh, Kazemi-Rad Elham, Roozafzoon Reza, Sianati Hamed, Rezaeian Mostafa, Heidari Mansour
Abstract excerpt
Acanthamoeba T4 genotype is the most prevalent genotype associated with amoebic keratitis. Acanthamoeba keratitis therapy is difficult due to transformation of trophozoite to cyst stage, which hinders the treatment of the disease. Although encystation assists the organism to survive against the chemotherapeutic compounds, the precise mechanism of encystation remains poorly understood. The purpose of this work was...
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