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Article

Immunological coagulation dual axis stratification identifies ultra high-risk phenotypes in systemic sclerosis.

Frontiers in immunology - 1 Jan 2026

Zhao Yaqi, An Yan, Yang Qingrui, Ma Zhenzhen

Abstract excerpt

Objective: Systemic sclerosis is a heterogeneous autoimmune disease characterized by complex interplay among immune activation, inflammation, coagulation, and fibrinolysis. This study aimed to construct a comprehensive immune-inflammation-coagulation-fibrinolysis (IICF) network and to evaluate its topological features and prognostic value across distinct organ involvement phenotypes. Methods: A total of 287...

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Identifiers

PMID: 42465738
DOI: 10.3389/fimmu.2026.1866374
PMCID: PMC13372969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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