Divergent mitochondrial and fibrotic signatures in atrial fibrillation: insights from organoids and GEO data.

doi:10.1186/s12933-026-03291-0

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Article

Divergent mitochondrial and fibrotic signatures in atrial fibrillation: insights from organoids and GEO data.

Cardiovascular diabetology - 11 Jul 2026

Won Jihee, Jung Hyocheol, Kim Jin Chul, Jeong Ji-Eun, Park Young Il, Uricoli Biaggio, Lee Sanghee, Son Young Hoon, Jeong Gun-Jae

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) remains a major clinical burden because structural and metabolic remodeling, particularly mitochondrial dysfunction and fibrosis, often persists beyond rhythm control. Human-relevant models that disentangle these axes and connect them to patient data are limited. METHODS: Human atrial organoids were exposed to two AF-relevant stressors: rapid pacing (FP) and angiotensin II...

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Topics

Humans
Atrial Fibrillation
Fibrosis
Organoids
Angiotensin II
Heart Atria

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mitochondria, Heart

Atrial Remodeling

Signal Transduction

Transcriptome

Databases, Genetic

Gene Expression Profiling

Cardiac Pacing, Artificial

Myocardial Contraction

Energy Metabolism

Phenotype

Oxidative Stress

Source

Open in PubMed Open full text

Identifiers

PMID: 42436472
DOI: 10.1186/s12933-026-03291-0
PMCID: PMC13602660

Genes

COL1A1

Provenance

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