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Article

Genetic evidence for causality between thyroid function and endometriosis: A bidirectional 2-sample Mendelian randomization study.

Medicine - 10 Jul 2026

Luo Jiahuan, Zhang Ruopeng, Song Mengjie, Zuo Liqin, Wang Shunqing, Liu Rongju, Rao Meng, Tang Li

Abstract excerpt

Accumulating observational evidence suggests an association between thyroid function and endometriosis, though the causal relationship remains unclear. To investigate potential bidirectional causal relationships, including for endometriosis subtypes, we conducted a bidirectional 2-sample Mendelian randomization (MR) analysis utilizing summary genetic data. Data sources included the ThyroidOmics Consortium (free...

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Endometriosis
Genetic Predisposition to Disease
Hyperthyroidism
Hypothyroidism
Mendelian Randomization Analysis

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PMID: 42432977
DOI: 10.1097/MD.0000000000049666
PMCID: PMC13363020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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