Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk.

doi:10.1002/ohn.70333

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Article

Development of Novel mRNA Classifiers to Stratify Preoperative Thyroid Tumor Risk.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Sept 2026

Barrett Thomas F, Jama Mohamed, Alshalalfa Mohammed, Tharakan Theresa, Hao Yangyang, Klopper Joshua P, Cavazos Taylor B, Jackson Ryan S, Pipkorn Patrik, Rich Jason T, Zolkind Paul A, Adkins Douglas R, Oppelt Peter, Apicelli Anthony J, Rammohan Nikhil, Brown Taylor C, Puram Sidharth V, Jasim Sina, Harbison R Alex

Abstract excerpt

OBJECTIVE: Develop a preoperative risk classifier for guiding the extent of surgery in differentiated thyroid carcinomas (DTCs) under 4 cm. STUDY DESIGN: In silico study, validation with retrospective cohort. SETTING: Genomic data repositories, academic tertiary medical center. METHODS: Prognostic transcriptional groups and American Thyroid Association (ATA) risk groups in The Cancer Genome Atlas (TCGA) were used...

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