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Genetic Links Between Cancer and Coronary Atherosclerosis: A Mendelian Randomization Analysis.

Human mutation - 1 Jan 2026

Fan Yanan, Liu Miaomiao, Zhang Lifei, Liu Fei, Dong Jiantao, Zhang Mengyang, Zhang Lixiao, Sun Yun, Yao Wenjing, Geng Wei

Abstract excerpt

Background: While observational studies have indicated a potential link between cancer and coronary atherosclerosis, the relationship remains obscured by confounding factors. Elucidating a shared genetic basis may uncover common pathophysiological pathways. Methods: We employed a two-sample Mendelian randomization (MR) approach to evaluate causal relationships between 23 cancer types and coronary atherosclerosis....

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Identifiers

PMID: 42428245
DOI: 10.1155/humu/5997499
PMCID: PMC13346356

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