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Article

Investigating Age-Related Differences in Survival Outcomes and Mutation Status of Patients with Intrahepatic Cholangiocarcinoma.

Annals of surgical oncology - 1 Oct 2026

Armstrong Misha, Kalvin Hannah, Gönen Mithat, Abou-Alfa Ghassan, Balachandran Vinod P, Cercek Andrea, D'Angelica Michael I, Harding James, Kingham T Peter, O'Reilly Eileen, Soares Kevin C, Wei Alice C, Jarnagin William

Abstract excerpt

BACKGROUND: Survival outcomes for intrahepatic cholangiocarcinoma (IHC) remain poor due to late-stage presentation and limited effective treatment options. Previous studies have suggested age-related differences in outcome, but the results are mixed, and there is substantial variation in the definition of "young." METHODS: A retrospective review analyzed 938 consecutive patients with a diagnosis of IHC between...

Read the complete abstract on PubMed

Topics

Humans
Cholangiocarcinoma
Female
Bile Duct Neoplasms
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

Mutation

Male

Survival Rate

Aged

Age Factors

Prognosis

Biomarkers, Tumor

Follow-Up Studies

Receptor, Fibroblast Growth Factor, Type 2

Aged, 80 and over

Adult

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 42426481
DOI: 10.1245/s10434-026-20199-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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