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High-resolution HAV genotyping using amplicon-based NGS read mapping and quantification.

Diagnostic microbiology and infectious disease - 1 Nov 2026

Chen Huiping, Löve Arthur, Ármannsdóttir Brynja, Kuriata Natalia, Mazur Katarzyna Zofia, Sæmundarson Magnús Máni, Ágústsson Axel

Abstract excerpt

BACKGROUND: High-resolution genotyping of Hepatitis A virus (HAV) is crucial for molecular surveillance and outbreak investigation. Traditional Sanger sequencing of the VP1/2A region is commonly used but struggles with mixed infections. OBJECTIVES: This study aims to develop and validate an amplicon-based next-generation sequencing (NGS) method for precise HAV genotyping and mixed infection detection, along with...

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PMID: 42418942
DOI: 10.1016/j.diagmicrobio.2026.117538

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