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Article

MET-amplified gastric cancers exhibit co-amplifications of BRAF, CDK6, and EGFR.

The journal of pathology. Clinical research - 1 Jul 2026

Lüschen Silke, Ebert Ulrike, Behrens Hans-Michael, Krüger Sandra, Ulase Dita, Amallraja Anu, Heckl Steffen M, Becker Thomas, Rosenstiel Philip, Meißner Tobias, Röcken Christoph

Abstract excerpt

MET-positive gastric cancer (GC) has a poor prognosis. In addition, targeting MET with monoclonal antibodies or tyrosine kinase inhibitors had limited success. We searched for additional genetic alterations that might explain the poor outcome of MET-positive GC and lack of response to MET-targeted therapies. Multiregional whole-exome sequencing was performed on primary tumor and lymph node metastasis samples from...

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Topics

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Share to Cyclin-Dependent Kinase 6
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Gene Amplification

Share to In Situ Hybridization, Fluorescence

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins c-met

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42417171
DOI: 10.1002/2056-4538.70104
PMCID: PMC13343299

Genes

MET
EGFR
CDK6
BRAF
GC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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