Article
Higher frequency of subclonal anti-EGFR resistance mutations in post-treatment samples from patients with colorectal cancer liver metastases following anti-EGFR-based conversion chemotherapy.
PloS one - 1 Jan 2026
Steup Christoph, Mondorf Antonia, Wild Peter, Pession Ursula, Bechstein Wolf Otto, Michael Florian A, Winter Melanie, Bein Julia, Zeuzem Stefan, Trojan Jörg, Koch Christine
Abstract excerpt
BACKGROUND/AIMS: Initially unresectable colorectal liver metastases may become resectable after chemotherapy. The acquisition of somatic mutations has been demonstrated to indicate evolving tumor subclones resistant to therapy and hinder R0 resection. However, the added value of mutational profiling in a real-world setting remains to be elucidated. The objective of the present study was to identify recurrent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.